Indian Frankincense, Boswellia
The dry extract obtained from the gum-resin from Boswellia tree is a powerfull antiinflamatory, used for the treatment of rheumatoid arthritis, inflammatory processes, inflammation and arthritic conditions, osteoarthritis, juvenile rheumatoid arthritis, myositis and fibrositis and colitis.
- Origen: Plant Based
- Fuente: Itself
- Tipo: Bioactive Compounds
- Rango de edad: Adults (18-60)
- Toxicidad: May be toxic in high doses
- Outcomes: Salud de Los Huesos y Articulaciones, Síntomas de La Osteoartritis
What are Boswellia benefits?
Table of relations
Published articles about Boswellia and Síntomas de La Osteoartritis
Eficacia y seguridad de Meriva®, un complejo de curcumina-fosfatidilcolina, durante la administración extendida en pacientes de osteoartritis.
Curcumin, dosed at 1,000mg MERIVA (curcumin bound to phosphatidylcholine) taken in two divided dosages of 500mg, was safe and effective over a period of 8 months in alleviating clinical and biochemical symptoms of osteoarthritis in a population of middle-aged (43+/-2) persons with osteoarthritis. Reductions were noted in IL-6 (27%), IL-1b (65%), and cell adhesion factors.
Un ensayo controlado aleatorizado sobre la eficacia y la seguridad de un ingrediente alimentario, hidrolizado de colágeno, para mejorar la comodidad conjunta
In patients with osteoarthritis given 10g hydrolyzed collagen over six months appeared to reduce pain assessed by VAS and WOMAC, although no other parameter on WOMAC (stiffness, function, or total score) was affected by treatment relative to placebo.
A study in 60 people with advanced rheumatoid arthritis given supplementation of solubilized collagen (0.1mg for one month then 1mg for the next) noted a reduction in joint pain and stiffness to a degree greater than placebo, with four subjects reporting resolution of symptoms dependent on supplementation (as symptoms reemerged after three months supplement cessation).
Seguridad y eficacia del colágeno tipo II sin mesada en el tratamiento de la osteoartritis de la rodilla: un ensayo clínico
Supplementation of 40mg UC-II (undenatured CII) once daily for three months was able to improve symptoms of osteoarthritis as assessed by WOMAC, VAS, and Lequesne rating scales. The potency was comparable to a combination of glucosamine HCl (1,500mg) and chondroitin sulphate (1,200mg) on Lequesne and VAS, and more effective on WOMAC. There was no placebo control used in this study and medication was relatively well tolerated.
Tratamiento de la artritis reumatoide con colágeno oral tipo II. Resultados de un ensayo multicéntrico, doble ciego, controlado con placebo
Supplementation of four doses of CII to rheumatic patients (20mcg, 100mcg, 500mcg, or 2.5mg) over 24 weeks noted that the lower doses were associated with higher response rates than the higher doses, with the 19% response seen in placebo being outperformed by a 39% response in the 20mcg group (25% response in 2.5mg was not statistically significant). Response was determined by at least a 30% reduction in joint soreness with responses on ACR and the Paulus criteria, and when looking only at the 30% reduction in pain all treatment groups (excluding ACR and Paulus) performed somewhat equally. IgA and IgG antibodies were detected only in a few subjects, and appeared to predict responsiveness to therapy at all doses despite their specificity to CII or overall amounts being affected.
Tratamiento curculotroideo para la osteoartritis de la rodilla: un ensayo controlado por placebo doble ciego al azar
In a randomized, double-blind, placebo-controlled trial, 53 people with knee osteoarthritis were assigned to take 1,500 mg of a curcuminoid complex (95% curcuminoids) with 15 mg of piperine or placebo daily for 6 weeks. 25% of participants didn't complete the study and weren't analyzed. The primary outcome was the change in the Western Ontario And McMaster Universities Osteoarthritis Index (WOMAC), which assessed osteoarthritis symptoms broadly, including pain, function, and stiffness. The curcuminoid group saw a notable, statistically significant reduction in the global WOMAC scale score and pain, and an improvement in function compared with the placebo group, but not for stiffness. The secondary outcomes were pain on a visual analog scale, and score on the Lequesne’s pain functional index and the curcuminoid group saw notable, statistically significant improvements compared with the placebo group for both. The participants in the curcuminoid group tended to use fewer NSAIDs over the course of the study.
Registro de evaluación de productos de Meriva®, un complejo de cúpula-fosfatidilcolina, para la gestión complementaria de la osteoartritis
200mg of MERIVA, taken at 200mg daily, was able to reduce symptoms of osteoarthritis and joint pain as assessed by the WOMAC rating scale and improve physical performance. C-Reactive Protein decreased only in the group with higher CRP at baseline, although to a very large degree (168 to 11.3mg/L)
Seguridad y eficacia del extracto de Longa de Curcuma en el tratamiento de la osteoartritis dolorosa de rodilla: un ensayo aleatorizado controlado con placebo
In a randomized, single-blind, placebo-controlled trial, 120 participants with knee osteoarthritis were assigned to take either 1,000 mg of a turmeric extract (Turmacinᵀᴹ), 1,500 mg of glucosamine sulfate, the combination, or placebo daily for 6 weeks. The primary outcomes were pain, as assessed by visual analog scale (VAS) and Western Ontario and McMaster. Universities Osteoarthritis Index (WOMAC) and function as assessed by WOMAC. Pain on the VAS for the turmeric group was dramatically reduced compared with placebo and the combination group and was reduced more than in the glucosamine group, but this wasn't statistically significant. The reduction in WOMAC rating was also much larger and statistically significant compared with placebo, while only modestly larger than compared with placebo and the combination group. Clinical Global Impression change in the turmeric group was significantly greater than for placebo and glucosamine, but not for the combination, though the turmeric-only group saw a greater reduction. The joint tenderness, crepitation, effusion, and terminal limitation of movement were all significantly and potently reduced in the turmeric group compared with baseline, while the placebo group only saw modest reductions, none of which were statistically significant. No notable difference in adverse events was found compared with placebo, and participants in the turmeric group were less likely to use acetaminophen as a rescue medication.
Efectos a corto plazo de la curcumina altamente biodisponible para tratar la osteoartritis de la rodilla: un estudio prospectivo aleatorizado, doble ciego, controlado con placebo.
In a randomized, double-blind, placebo-controlled trial, 50 participants with knee osteoarthritis were assigned to take 180 mg of curcumin (Theracurcumin) or placebo daily for 8 weeks. 18% of participants didn't complete the study and weren't analyzed. The curcumin group saw a notable reduction in pain compared with the placebo group, which was only statistically significant for the subset of participants with initial VAS scores of 0.15. Osteoarthritis symptoms as measured by the Japanese Knee Osteoarthritis Measure (JKOM) were somewhat improved in the curcumin group compared with the placebo group, but the difference wasn't statistically significant. The curcumin group tended to use less celecoxib than the placebo group throughout the study.
Eficacia y seguridad de la curcumina y su combinación con ácido boswellic en osteoartritis: un estudio comparativo, aleatorizado, doble ciego y controlado con placebo
In a randomized, double-blind, placebo-controlled trial, 201 participants with degenerative hypertrophic osteoarthritis were assigned to take 1,500 mg curcuminoids (BCM-95), 1050 mg curcuminoids with 450 mg Boswellia serrata, or placebo for 12 weeks. The primary outcomes were osteoarthritis pain and function assessed by WOMAC, and physical performance was assessed by OARSI-recommended tests. Total WOMAC score was somewhat reduced in the curcumin and combination groups compared with placebo, but only the combination group saw a statistically significant reduction. Pain was significantly improved compared with placebo in the combination group, but not stiffness or function, and while the curcumin group saw improvements compared with placebo, none of these were statistically significant. For the OARSI-recommended tests, the curcumin group saw notable, statistically significant improvements compared with the placebo group for the chair stand test and fast-paced walk test speed, but not for the time up and go test, or stair climb test, though it did see improvements. The combination group saw statistically significant improvements for all. There were no notable differences in adverse events between the curcumin and placebo groups (3% and 5.6% respectively), and the combination group saw somewhat more than either (10.6%).
Eficacia y seguridad de los extractos de Curcuma Domestica en comparación con el ibuprofeno en pacientes con osteoartritis de la rodilla: un estudio multicéntrico
In a randomized, single-blind, trial, 367 participants with knee osteoarthritis were assigned to take 1,500 mg of a turmeric extract (total curcuminoids content between 75% and 85%) or 800 mg of ibuprofen daily for 4 weeks. The primary outcomes were pain, stiffness, and function on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Both groups saw notable reductions in all measures, with no clinical or statistically significant difference between them. Adverse events were observed in 35.7% of ibuprofen users and 29.7% of turmeric extract users, with no statistically significant difference.
Un estudio de grupo paralelo aleatorizado, doble ciego, placebo, con control paralelo para evaluar la seguridad y la eficacia de Curene® versus placebo en la reducción de los síntomas de la rodilla OA
In a randomized, double-blind, placebo-controlled trial, 50 patients with knee osteoarthritis were assigned to take 500 mg (>20% total curcuminoids) of a novel, highly bioavailable turmeric extract for 60 days. The primary outcome was a global score of osteoarthritis symptoms (WOMAC). The turmeric group saw a large, statistically significant improvement in all osteoarthritis symptoms compared with placebo, The turmeric extract group also saw a large and statistically significant reduction in pain compared with the placebo group, as measured by a visual analog scale. There was no noted difference in the rate of adverse events between groups, and the rate was low for both. The group that received the turmeric extract began to take less pain medication than the placebo group.
La eficacia de Curcuma Longa L. Extracto como terapia adyuvante en la osteoartritis primaria de la rodilla: un ensayo de control aleatorizado
In a randomized, double-blind trial, 44 participants with knee osteoarthritis were assigned to take diclofenac alone or diclofenac with 500 mg of curcuminoids daily for 3 months. Both groups saw a similar reduction in pain as measured by a visual analog scale, with no statistically significant difference between them. For the Knee injury and Osteoarthritis Outcome Score, function in sport and recreation, quality of life, and symptoms categorized as 'other' were similarly improved in both groups with no statistically significant difference. The curcumin group saw a more considerable improvement in function in daily living and pain, but these weren't statistically significant.
Seguridad y eficacia de la curcumina versus diclofenac en la osteoartritis de la rodilla: un estudio de brazo paralelo aleatorizado de etiqueta abierta
In a randomized, open-label comparator trial, 149 patients with knee osteoarthritis were allocated to take 500 mg of curcuminoids (BCM-95) 3 times per day or 50 mg of diclofenac twice per day for 28 days. The primary outcome was the improvement in pain on a visual analog scale (VAS), and the improvement in the curcumin group saw large and statistically significant compared with baseline and roughly the same as for diclofenac. Pain on the Knee Injury and Osteoarthritis Outcome Score was greatly improved in both groups as well, as was function and quality of life, without notable differences between them.
Curcuma Longa Extracto reduce los biomarcadores inflamatorios y oxidativos del estrés en la osteoartritis de la rodilla: un ensayo de cuatro meses, doble ciego, aleatorizado y controlado con placebo
In a randomized, double-blind, placebo-controlled trial, 160 patients with knee osteoarthritis were allocated to take 500 mg of curcuma longa extract or placebo daily for 4 months, alongside diclofenac. The primary outcomes were pain on a visual analog scale and osteoarthritis severity on the WOMAC scale, and the intervention group saw a modestly greater improvement in pain on the visual analog scale that was statistically significant and a somewhat greater improvement in pain on WOMAC (p=0.06). There was no difference in stiffness, though there was a small, statistically significant improvement in physical function that was statistically significant between groups. There was a greater reduction in reactive oxygen species and malondialdehyde in the intervention group. Joint crepitation and effusion were also significantly reduced in the intervention group, and there were no meaningful differences in adverse events.
Glucosamine hydrochloride failed to cause a significant protective effect in osteoarthritis, while evidence on sulfate (statistically significant of a low magnitude) was said to be confounded with industry influence. No publication bias reported
Glucosamina, sulfato de condroitina y los dos en combinación para la osteoartritis dolorosa de rodilla
The GAIT trial noted that 1500mg Glucosamine in isolation failed to significantly influence a reduction of pain in persons with osteoarthritis over 6 months; combination therapy with Chondroitin was effective only in the cohort of persons with more pain at baseline
Uso de sulfato de glucosamina y retraso de la progresión de la osteoartritis de la rodilla: un estudio de doble ciego de 3 años, aleatorizado, controlado por placebo
The progression of osteoarthritis associated with 1,500mg Glucosamine sulfate for 3 years appeared to be reduced as assessed by joint space loss relative to placebo and pain.
Sulfato de glucosamina en el tratamiento de los síntomas de la osteoartritis de la rodilla: un estudio aleatorizado, doble ciego, controlado con placebo que usa el acetaminofeno como comparador lateral
1,500mg Glucosamine had equal efficay to 3g acetominophen for reducing joint pain in persons with osteoarthritis; this trial (the GUIDE trial) may be influenced by a producer of Glucosamine supplemnetation
Efectividad de la glucosamina para los síntomas de la osteoartritis de la rodilla: los resultados de un ensayo controlado de doble ciego aleatorio basado en Internet
(Internet based study) Mostly glucosamine sulfate, although a switch to hydrochloride for 20% of the sample was needed, failed to outperform placebo in regards to symptoms of osteoarthritis and pain.
Eficacia estructural y sintomática de la glucosamina y la condroitina en la osteoartritis de la rodilla: un metanálisis integral
A meta-analysis of 15 studies (inclusive of glucosamine and combination therapy of glucosamine with chondroitin; 7 studies used glucosamine sulfate) noted a significant effect on all measured outcomes of glucosamine treatment. Funnel plot analysis failed to find evidence of publication bias, although it appeared to trend close (and was said to be from influence from smaller studies with more effect size)
Efectos de la glucosamina, la condroitina o el placebo en pacientes con osteoartritis de cadera o rodilla: metanálisis de la red
A network meta-analysis on glucosamine sulfate found statistically significant pain relief, but deemed that the clinical significance of this pain relief was minimal.
Eficacia y seguridad de los extractos de Curcuma Domestica en pacientes con osteoartritis de la rodilla
2g/day of Curcumin extract has an effect equal to ibuprofen for treatment of knee osteoarthritis
El extracto de Curcuma BIO-optimizado de Curcuma es eficiente en el dolor de la osteoartritis de la rodilla: un estudio de tres brazos controlado con placebo aleatorizado de doble ciego multicéntrico
In a randomized, double-blind, placebo-controlled trial, 150 participants with knee osteoarthritis were allocated to either placebo, approximately 187 mg of a turmeric rhizome extract, or 280 mg daily for 3 months. 74 participants completed the entire trial, while 141 were able to be included in the intention to treat analysis. At the end of 3 months, both curcumin groups saw a statistically significantly greater improvement in Patients Global Assessment of Disease Activity score than placebo, and there were no statistically significant differences between them. Markers of collagen breakdown were reduced significantly in the curcumin groups but not the placebo group. Pain on the visual analog scale was significantly improved compared with placebo in both curcumin groups, with no notable differences between them. Symptoms on the Knee injury and Osteoarthritis Outcome Score were improved more in the curcumin groups, with the greatest improvement in the high-dose group, but there were no statistically significant differences between groups.
Evaluación clínica doble ciega del sulfato de glucosamina oral en el tratamiento básico de la osteoartrosis
1,500mg Glucosamine sulfate daily over 6-8 weeks noted a reduction of pain associated with osteoarthritis when compared to placebo
Un ensayo aleatorizado, doble ciego, controlado con placebo de sulfato de glucosamina como analgésico en osteoartritis de la rodilla.
6 months of supplementation with 1500mg glucosamine sulfate was unable to outperform placebo.
An updated (2005) Cochrane analysis of 20 trials on glucosamine sulfate found a significant protective effect of glucosamine treatment, with the test for publication bias not reaching significance and thought to be influenced by factors not involved with publication bias (effect sizes from smaller trials)
Efecto del clorhidrato de glucosamina en el tratamiento del dolor de la osteoartritis de la rodilla.
Glucosamine hydrochloride at 1500mg daily was unable to outperform placebo during an 8 week placebo controlled study.
Glucosamine sulfate at 1,500mg for 2 months failed to significantly reduce symptoms of osteoarthritis
La medicina ayurvédica ofrece una buena alternativa a la glucosamina y celecoxib en el tratamiento de la osteoartritis sintomática de la rodilla: un ensayo aleatorizado, doble ciego, controlado por drogas de equivalencia controlada
In persons with osteoarthritis, 2g of Glucosamine appeared to be as effective as 200mg Celecoxib over 6 months in reducing joint pain.
Efectos a largo plazo del sulfato de glucosamina en la progresión de la osteoartritis: un ensayo clínico aleatorizado y controlado con placebo
3 years of supplementation of 1500mg Glucosamine was associated with a reduced rate of joint space loss in persons with low grade osteoarthritis.
Estudio aleatorizado, doble ciego, paralelo, controlado con placebo de glucosamina oral, metilsulfonilmetano y su combinación en osteoartritis
1,500mg glucosamine sulfate outperformed placebo in reducing pain in persons with knee osteoarthritis, and was additive with supplemental MSM (another group tested the combination)
Resultados clínicos comparables entre la glucosamina sulfato-cloruro de potasio y el cloruro de sodio de sulfato de glucosamina en pacientes con osteoartritis de rodilla suave y moderada: un estudio aleatorizado y doble ciego
Glucosamine Sulphate as either a potassium salt or a sodium chloride salt were both effective in reducing knee osteoarthritis, with no significant differences between the two. No placebo control group.
Los efectos del concentrado de proteína de la leche en los síntomas de la osteoartritis en adultos: un ensayo exploratorio, aleatorizado, doble ciego y controlado con placebo
A trial comparing the effects of milk protein on osteoarthritis using glucosamine as active control noted that, in a comparison of glucosamine to placebo, that glucosamine sulfate at 1,500mg was able to protect from osteoarthritis over 6 weeks
Glucosamina y condroitina para el tratamiento de la osteoartritis: una evaluación sistemática de la calidad y el metanálisis
This meta-analysis was able to find a significant protective effect of glucosamine sulfate in 5 trials but also found publication bias present as assessed by funnel plot analysis
Un estudio doble ciego, aleatorizado, controlado con placebo de la eficacia y seguridad de la 5-loxina para el tratamiento de la osteoartritis de la rodilla.
100mg or 250mg 5-Loxin (30% AKBA) was able to confer benefits to multiple rating scales of joint pain relief in persons with osteoarthritis.
Un estudio clínico controlado con doble ciego, aleatorizado y controlado con placebo evalúa la eficacia temprana de la aflapina en sujetos con osteoartritis de rodilla.
100mg of 20% AKBA Boswellia was able to reduce all measured parameters of osteoarthritis in persons over the course of 30 days.
Evaluación clínica de la resina Boswellia Serrata (WALLAKI) en la gestión de Sandhivata (osteoartritis)
6g of the basic plant Boswellia Serrata was able to significantly attenuate joint pain and symptoms in persons with osteoarthritis.
Eficacia comparativa y tolerabilidad de la osteoartritis de 5-LOXIN y AFLAPINAINST de la rodilla: un estudio clínico con control de doble ciego, aleatorizado y controlado con placebo
Relative to placebo, 100mg of Boswellia standardized to 30% AKBA was able to reduce joint pain and stiffness on multiple rating scales in persons with confirmed osteoarthritis over 7 days, with maximal effects over 90 days
Eficacia de la suplementación con metilsulfonilmetano en osteoartritis de la rodilla: un estudio controlado aleatorizado
MSM supplementation at 3.375g daily for 12 weeks was associated with overall improvements in the symptoms of osteoarthritis and although a pain reducing effect was apparent it was so variable it failed to reach statistical significance. Perhaps the most marked difference was a reduction of stiffness by 26% in MSM while placebo increased 37%, but this was also so variable that it failed to reach significance. There were some differences (gender and BMI) between groups at baseline, although the MSM group tended to weigh more.
Oral supplementation of CII in young subjects with juvenile rheumatoid arthritis appeared to have benefits in reducing symptoms over the course of three months of supplementation when compared to baseline in 8/10 subjects with one remission (although spontaneous remission is possible with untreated juvenile rheumatism); there was no placebo group for comparison.
Tratamiento de la osteoartritis con Pycnogenol. El SVOS (estudio de osteo-artrosis de San Valentino). Evaluación de signos, síntomas, rendimiento físico y aspectos vasculares.
In persons with osteoarthritis given 100mg pycnogenol once daily for 3 months, supplementation was able to more than half (56% reduction) symptoms of osteoarhritis as assessed by the WOMAC rating scale. An improvement in functional scores and reduction in foot edema was also noted (parameter recorded under leg swelling).
La suplementación con Pycnogenol reduce el dolor y la rigidez y mejora la función física en adultos con la osteoartritis de la rodilla
In persons with primary grade 1 osteoarthritic symptoms, supplementation of pycnogenol at 50mg thrice daily was noted to, over the course of 90 days, reduce pain and functional impairment associated with osteoarthritis in the range of 35-52% (depending on what was being measured). It took 90 days for this magnitude of benefit to be see, and although all but stiffness benefitted slightly by 60 days there was no effect on day 30.
La osteoartritis es una enfermedad crónica muy común entre los ancianos que afecta huesos y cartílagos. Los síntomas incluyen dolor articular en las manos, cuello, espalda baja, rodillas o caderas, así como dificultad para moverse.
Related videos about Boswellia
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